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怀孕和哺乳期个体对新型B组链球菌疫苗的看法
Monica Sosa1, Candace Haghighi2, Mindy Pike1
1From the Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington.
The Pediatric infectious disease journal
|February 14, 2025
概括
在怀孕期间,新型B组菌 (GBS) 疫苗临床试验的可接受性是混合的,但在哺乳期更高. 大多数参与者更喜欢基于蛋白质或mRNA的疫苗平台.
科学领域:
- 产科和妇科 产科和妇科
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 针对B组链球菌 (GBS) 的多价值合疫苗正在开发中,用于母体免疫.
- 了解孕妇和哺乳期患者对新型GBS疫苗的看法至关重要,特别是在COVID-19疫苗经验之后.
研究的目的:
- 评估怀孕和哺乳期患者对新型GBS疫苗临床试验参与的知识和可接受性.
- 在这些人群中探索GBS疫苗平台的偏好.
主要方法:
- 在正在进行的基于调查的前性队列研究中,对参与者进行了后续调查.
- 该调查包括关于GBS知识和愿意参加GBS疫苗临床试验的问题.
- 通过REDCap在线收集了14903名参与者的数据.
主要成果:
- 与非孕妇/哺乳期患者相比,孕妇在怀孕期间参加GBS疫苗试验的可能性较低 (P < 0.001).
- 与非孕妇/哺乳期患者相比,哺乳期患者在哺乳期更有可能参加GBS疫苗试验 (P < 0.001).
- 首选的疫苗平台包括基于蛋白质 (70.5%) 和基于mRNA (71.5%) 的技术.
结论:
- 参与者表现出对GBS有很好的理解.
- 怀孕期间新型GBS疫苗试验的可接受性是混合的,但在哺乳期更高.
- 孕妇和哺乳期患者的观点对于开发新的GBS疫苗至关重要.
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