相关实验视频
Updated: May 28, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
接种百日咳疫苗后母乳中的抗体在怀孕期间的三次窗口中
Olwenn Daniel1, Myles Loughnan1,2, Miranda Quenby1,3
1From the Centre for Neonatal and Paediatric Infection and Vaccine Institute, School of Health & Medical Sciences, City St George's, London, UK.
孕妇在怀孕期间接种百日咳疫苗的时间不会影响母乳中的特定IgA水平. 这一发现对于在母体免疫接种后通过母乳养优化婴儿粘膜免疫是至关重要的.
科学领域:
- 免疫学 免疫学 免疫学
- 母婴健康 孕产妇和婴儿健康
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在英国,在怀孕期间 (16-32周妊娠期) 建议使用含有百日咳的疫苗.
- 关于最佳的疫苗接种时间来获得母婴福利存在争议.
- 母乳IgA对婴儿粘膜免疫至关重要,其度可能会受到母亲接种疫苗的时间的影响.
研究的目的:
- 调查孕妇在怀孕期间接种咳疫苗的时间是否会影响母乳IgA度.
- 根据不同的疫苗接种计划,评估乳酪和成熟母乳中的抗原特异性IgA水平.
主要方法:
- 参与者在不同的妊娠期 (在24周之前,24-27+6周之前,或28-31+6周之前) 接种了含有 pertussis 的疫苗.
- 分别在分娩后24小时内和分娩后14天内采集了胆乳和母乳样本.
- 多重免疫试验用于测量针对百日咳毒素,毒素,毒素和白喉毒素的特定IgA水平.
主要成果:
- 疫苗接种时间组之间没有观察到针对测试抗原的特定IgA水平的显著差异.
- 对所有参与者来说,在产后14天内,从胆乳到母乳的抗原特异性IgA水平普遍下降.
结论:
- 在怀孕期间服用含有百日咳疫苗的时间似乎没有影响14天后乳酪或母乳中的抗原特异性IgA度.
- 这些发现支持目前的疫苗接种指南,建议在时间上灵活,而不影响被动免疫转移的这一方面.
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