最近侵袭性细菌感染的增加:国家COVID队列协作小组的报告
Blake Martin1,2, Peter E DeWitt2, Seth Russell2
1From the Section of Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
The Pediatric infectious disease journal
|February 14, 2025
概括
病毒性呼吸道感染 (VRIs) 在COVID-19后急剧增加,增加了儿童肺炎和鼻炎等侵入性细菌感染 (IBIs). 流行性RSV和流感与鼻炎相关,但其他VRI-IBI链接减弱.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- COVID-19缓解措施的减弱导致病毒性呼吸道感染 (VRIs) 的增加.
- 这种VRI的激增可能会增加二次侵入性细菌感染 (IBI) 的风险.
- 了解特定VRIs和IBIs之间不断变化的关系对于公共卫生至关重要.
研究的目的:
- 评估病毒性呼吸道感染 (VRIs) 和侵入性细菌感染 (IBIs) 流行病学的变化.
- 评估特定的VRIs (例如RSV,流感) 和随后的IBIs (例如复杂的肺炎,鼻炎,侵入性A组链球菌) 之间的时间关系.
- 分析这些趋势使用国家COVID队列协作 (N3C) 数据集.
主要方法:
- 从58个N3C机构前收集的儿科和成人患者接触的二次分析.
- 为了比较,数据被分为流行病前和流行病时代.
- 分析了VRI和IBI病例之间的特征,结果和相关性.
主要成果:
- 与大流行前相比,大流行时期的儿童每月发生的腺病毒,侵袭性A型 estreptococcus (iGAS),复杂的肺炎和复杂的鼻炎的平均病例较高.
- 在大流行时期的儿童中,呼吸道综合细胞病毒 (RSV) 和流感病例与随后复杂的鼻炎病例有显著的相关性.
- 在大流行期间,其他VRI-IBI对之间的相关性通常是温和的,并且通常低于大流行前的时代.
结论:
- 自COVID-19出现以来,每月平均iGAS病例,复杂肺炎和复杂鼻炎病例的增加.
- 流行病时代的RSV和流感感染与儿童随后复杂的鼻炎相关.
- 尽管存在特定的相关性,但许多其他VRI-IBI关系在大流行期间显示相关性下降.
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