人类指数与慢性病之间的关联:来自NHANES 2009-2018年的见解
Xinyun Chen1, Zheng Wu2, Xingyu Hou3
1Department of Nephrology, Kidney Research Institutes, West China Hospital, Sichuan University, Chengdu, China.
PloS one
|February 14, 2025
概括
新的人类指数如ABSI和C指数比BMI更好地预测慢性病 (CKD) 风险. 这些措施为与肥胖相关的CKD提供了更好的洞察力,这对公共健康至关重要.
科学领域:
- 临床医学 临床医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
背景情况:
- 肥胖与慢性病 (CKD) 密切相关.
- 传统的肥胖指标,如身体质量指数 (BMI),由于身体组成的变化,对CKD的评估不够.
- 新的人类指数可能为CKD风险提供更好的预测价值.
研究的目的:
- 调查CKD与新型人类指数之间的关联.
- 为了比较身体形状指数 (ABSI),身体圆度指数 (BRI),腰与身高比率 (WHtR) 和度指数 (C-index) 与传统措施的预测能力.
主要方法:
- 分析国家健康和营养检查调查 (NHANES) 数据 (2009-2018).
- 权重多变量回归分析以评估独立关系.
- 进行了子组分析,受限立方线回归和ROC曲线分析.
主要成果:
- ABSI,BRI,WHtR和C指数与心脏病风险增加有显著的关联;BMI没有.
- 与BMI和腰围相比,ABSI和C指数显示出更高的预测能力 (最高AUC).
- 高度表明对CKD有保护作用.
结论:
- 几种人体指数,特别是ABSI和C指数,与CKD风险有显著的相关性.
- 与传统指标相比,ABSI和C指数为CKD提供了更强大的预测能力.
- 这些发现强调了先进的人类测量措施在CKD风险评估中的重要性.
相关概念视频
01:10Nature and Nurture
20.3K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.3K
01:10Nephrons
2.1K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.1K
01:21External Anatomy of the Kidney
690
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
690
01:33Hormonal Regulation
32.8K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.8K
01:45Kidney Structure
68.6K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
68.6K
01:12Internal Anatomy of the Kidney
1.2K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.2K