访问到访问的血压变化和不良围产期结果之间是否存在关系?
Laura Ormesher1, Jill Stewart2, Beth Renwick2
1Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, The University of Manchester, Manchester M13 9WL, United Kingdom; Saint Mary's Hospital, Manchester University NHS Foundation Trust, Manchester M13 9WL, United Kingdom.
Pregnancy hypertension
|February 14, 2025
概括
怀孕期间静脉压 (BP) 变化增加与胎儿生长限制和早产的风险更高有关. 需要进一步的研究来澄清BP不稳定性对围产期结局的直接影响.
科学领域:
- 产科和妇科 产科和妇科
- 心脏病学 心脏病学
- 围产儿医学 围产儿医学
背景情况:
- 怀孕期间的高血压是产生不良周产期结果的重要危险因素.
- 了解血压 (BP) 变化在妊娠并发症中的作用对于改善管理至关重要.
研究的目的:
- 调查访问到访问血压 (BP) 变化和围产期结局之间的关联,特别是胎儿生长限制 (FGR) 和早产 (PTB).
主要方法:
- 追溯分析996名患有高血压或风险因素的孕妇.
- 使用标准偏差 (SD) 和平均差 (MD) 量化BP变异性.
- 对混因子进行调整后勤回归模型,以评估BP变化和结果之间的关系.
主要成果:
- 访问到访问的缩血压变化增加与FGR和PTB都有显著的关联.
- 这些关联在调整多个混因素后仍然存在,但在调整最大BP时失去了意义.
- 与labetalol相比,nifedipine的使用与更高的BP变异性有关.
结论:
- 访问到访问的静脉血压变化,但不是透气,与不良的围产期结局有关.
- 对BP不稳定性与峰值BP对结果的直接影响仍然不清楚.
- 抗高血压药物之间血压变化的差异需要在前性研究中进一步调查.
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