抗菌剂通过抑制呼吸,诱导氧化应激,线粒体功能障碍和自的作用对水生生物产生有毒作用
Hagar Fadda1, Raheema Hassan Khan2, Yara Shqair2
1Faculty of Medicine and Science University of Fribourg Avenue de l'Europe 20, Fribourg 1700, Switzerland; Molecular Biology, Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956 Turkey.
废水中的杀菌抗生素通过破坏线粒体,破坏细胞呼吸和增加活性氧物种来损害水生生物. 这项研究强调了抗微生物污染带来的环境风险,影响了城市附近的生态系统.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 分子生物学分子生物学
背景情况:
- 杀菌抗生素在医学中至关重要,但它们在环境中的释放越来越令人担忧.
- 抗微生物药物通常被认为对低剂量的真核生物来说是安全的,但线粒体与原核生物有共同的起源.
- 由于暴露于抗生素的真核生物中的线粒体功能障碍是一个研究不足的领域.
研究的目的:
- 为了研究常见的杀菌抗生素对水生生物的线粒体的影响.
- 评估抗生素暴露对细胞和生物呼吸的影响.
- 探索毒性的机制,包括反应性氧物种的产生和自.
主要方法:
- 使用微型甲动物Artemia salina作为模型生物.
- 暴露于各种类型的抗生素的生物体:甲氨酸A,四环素化物,红氨酸和氨基醇.
- 测量了反应性氧物种的积累和观察到的自作为线粒体压力的指标.
主要成果:
- 对抗生素的暴露导致了Artemia salina中显著的线粒体功能障碍.
- 在不同的抗生素类别中观察到抑制细胞和生物呼吸.
- 增加反应性氧物种的产生和诱导自是一致的发现.
结论:
- 常见的杀菌抗生素对水生生态系统构成重大威胁.
- 线粒体毒性是这些药物影响水生生物的关键机制.
- 废水被抗菌素污染需要环境监测和管理策略.
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