活跃复发性复发性或二次渐进性多发性硬化症患者的管理:基于与第四阶段研究相关的索赔数据的法国现实研究
Xavier Moisset1, Grégoire Mercier2, Manon Belhassen3
1Université Clermont Auvergne, CHU Clermont-Ferrand, Inserm, Neuro-Dol, F-63000 Clermont-Ferrand, France.
Multiple sclerosis and related disorders
|February 14, 2025
概括
这项研究将临床数据与国家主张联系起来,以评估多发性硬化症 (MS) 的经济负担. 在复发性复发性多发性硬化症 (RRMS) 患者中,较高的残疾和复发率显著增加了医疗保健成本.
科学领域:
- 神经学 神经学
- 卫生经济学 卫生经济学
- 药物经济学 药物经济学
背景情况:
- 在PRO-MSactive研究中,评估了ocrelizumab在活性复发性复发性多发性硬化症 (RRMS) 和二级渐进性多发性硬化症 (SPMS) 中.
- 将临床数据与法国国家索赔数据库 (SNDS) 联系起来,以了解疾病负担.
研究的目的:
- 分析RRMS患者的医疗保健资源利用率和成本.
- 评估残疾和复发活动在奥克雷利祖马布治疗前两年的经济影响.
主要方法:
- 利用了PRO-MSactive研究 (2018年7月至2019年7月) 中291名RRMS和SPMS患者的数据.
- 将患者的临床数据与SNDS数据库进行链接,以进行成本分析.
- 基于扩展残疾状态量表 (EDSS) 分数 (<4对≥4) 和两年 (n-1和n-2) 的比较成本.
主要成果:
- 患有较高残疾的患者 (EDSS ≥4) 的医疗费用显著增加.
- 在n-2年,成本为9,103欧元 (<4 EDSS) 与16,441欧元 (≥4 EDSS) 相比;在n-1年,9,813欧元 (<4 EDSS) 与19,999欧元 (≥4 EDSS) 相比.
- 复发活动与n-2年和n-1年之间1,358欧元的成本增加相关.
结论:
- 这是第一个将IV期临床数据与索赔数据库集成的研究,以根据疾病类型和残疾区分多发性硬化症成本.
- 在具有较高残疾水平的RRMS患者中观察到更大的经济负担.
- 增加的医疗保健费用与研究入学前两年的复发活动有关.
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