西德克萨斯州休公园的迁徙中产生β-乳糖酶的埃舍里希亚大肠杆菌
Yamima Tasnim1, Md Kaisar Rahman1, Cherissa Abdul-Hamid2
1Texas Tech University School of Veterinary Medicine, Amarillo, TX 79106, United States.
Comparative immunology, microbiology and infectious diseases
|February 14, 2025
概括
西德克萨斯州的迁徙携带抗药性大肠杆菌,构成潜在的健康风险. 在参观这些鸟类存在的公园后,加强卫生至关重要.
科学领域:
- 环境微生物学环境微生物学
- 一个健康,一个健康.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 迁徙鸟类可以作为抗菌素耐药细菌的载体.
- 娱乐公园代表着野生动物,人类和物互动的界面,造成了健康的关注.
研究的目的:
- 为了确定在迁徙的便中抗beta-lactamase的埃舍里希亚大肠杆菌的流行率.
- 描述这些耐药大肠杆菌分离物的基因组特征.
- 评估西德克萨斯州休公园的潜在One Health影响.
主要方法:
- 描述性研究收集西德克萨斯州休公园的便,水和土壤样本.
- 使用Chromogenic agar. 用于隔离抗扩展谱β-乳糖酶 (ESBL) 的大肠杆菌.
- 全基因组测序 (WGS) 用于对选定的大肠杆菌分离物的基因组特征.
主要成果:
- 12.61%的样本对ESBL耐药的大肠杆菌呈阳性.
- 在20个分离物中,WGS发现了19个含有β-乳糖酶基因 (如blaCTX-M,blaTEM) 和抗四环素,氨基糖化物,硫胺胺,安非尼科尔,trimethoprim和链路蛋白B的基因.
- 隔离物与人类大肠杆菌菌株具有遗传相似性,并检测到等离子体组和毒性基因.
结论:
- 在休公园的迁徙是多抗药性大肠杆菌的储存库.
- 多种不同的大肠杆菌菌株的存在凸显了人类和物卫生习惯的重要性.
- 这项研究强调了微生物耐药性在环境和人类健康领域的相互联系.
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