阿斯塔ξαν丁可以通过调节酸水平来缓解脊髓神经绑定引起的神经病痛
Jingwu Li1, Daosong Dong1, Yanbin Sun2
1Department of Pain, The First Hospital of China Medical University, Shenyang, Liaoning Province, 110001, China.
概括
亚斯丁 (AST) 通过提高酸 (PA) 水平来缓解神经病痛 (NP),而这种水平在NP中会降低. 这项研究揭示了AST的一种新机制.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经病痛 (NP) 带来了重大的治疗挑战.
- 肠道微生物群的代谢物propionic acid (PA) 是NP的潜在治疗标,但其作用尚不清楚.
- 阿斯塔克桑丁 (AST) 对NP中PA水平的影响尚不清楚.
研究的目的:
- 调查PA在NP发展中的作用.
- 为了确定AST是否通过调节PA水平来减轻NP.
- 确定NP的新型治疗策略.
主要方法:
- 通过L4脊髓神经绑定 (SNL) 建立了NP的小鼠模型.
- 使用16S rRNA测序分析了肠道微生物组成.
- 在便,血液和脊髓中量化PA水平,使用GC-MS.
- 采用了网络药理学,分子对接,qPCR和西部斑块来识别和分析PA-NP相互作用.
主要成果:
- SNL小鼠表现出肠道失调和改变的PA代谢.
- 在NP小鼠的便,血清和脊髓中观察到降低的PA水平.
- 网络药理学确定了PA和NP之间共享的治疗点,主要是炎症调节.
- 外源性PA补充剂减少了肠道和脊髓中的疼痛和炎症 (NLRP3,NF-κB).
结论:
- AST治疗调节了肠道微生物群,增加了PA水平,减少了炎症,从而产生镇痛作用.
- 提高PA水平代表了AST缓解疼痛的潜在新机制.
- AST增强了肠道屏障,有助于其在NP中的治疗效益.
相关概念视频
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
570
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
570
01:24Local Anesthetics: Differential Sensitivity of Nerve Fibers
751
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
751
01:23Local Anesthetics: Mechanism of Action
2.1K
Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
2.1K
01:25Analgesia and Pain Management
422
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
422
01:29Spasmolytic Agents: Chemical Classification
851
Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
851
01:44Nociception
27.7K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.7K