阻塞性睡眠呼吸暂停和2型糖尿病患者的夜间酸盐水平的性别特异性差异
Gregory Pappas1, Andrew Gow2, Naresh M Punjabi3
1Ernest Mario School of Pharmacy, Picastaway, NJ, USA; War Related Illness and Injury Study Center, VA New Jersey Healthcare System, East Orange, NJ, USA.
Sleep medicine
|February 14, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 对患有2型糖尿病的男性和女性的夜间酸盐水平有不同的影响. 男人经历下降,而严重OSA的女性没有,表明潜在的性别特异性氧化应激途径.
科学领域:
- 心血管科学 心血管科学
- 内分泌学 在内分泌学.
- 睡眠的药物 睡眠的药物
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与内皮功能障碍和减少氧化 (NO) 介导的血管扩张有关.
- 对OSA心脏代谢影响的性别特异性差异尚未完全理解.
- 氧化应激途径可能会调解OSA和心脏代谢结果之间的联系,并可能存在基于性别的变化.
研究的目的:
- 在2型糖尿病 (T2DM) 患者中调查OSA严重程度与一夜间氧化 (NO) 代谢物 (酸盐和酸盐) 之间的关联.
- 为了确定性别是否影响OSA严重程度和夜间NO代谢物水平之间的关系.
- 在T2DM患有OSA的患者中探索氧化应激标志物的潜在性别差异.
主要方法:
- 从社区中招募T2DM和未诊断的OSA的成年人.
- 收集人口统计数据,夜间多睡眠学和睡眠前后的血样本.
- 多变量线性回归分析,以评估OSA严重程度与酸盐/酸盐水平之间的关联,按性别分层.
主要成果:
- 这项研究包括83名参与者 (52%是男性).
- 在患有OSA的男性中,无论严重程度如何,夜间酸盐水平都下降了.
- 患有中度至重度OSA的妇女没有显示过夜酸盐水平的预期下降,在妇女中观察到重度OSA和睡眠后酸盐的显著相互作用.
结论:
- OSA和夜间酸盐水平之间的关系取决于性别,并受OSA严重程度的影响.
- 患有OSA的男性在夜间酸盐水平下降,这表明氧化应激增加.
- 患有严重的OSA的女性在一夜之间保持稳定的酸盐水平,这表明与男性相比,氧化应激反应可能不同.
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