设计用于VD3输送的水解大豆蛋白纳米颗粒:VD3纳入和重塑消化过程中的行为是消化问题
Zhicheng Niu1, Dan Yuan1, Mouming Zhao2
1School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Guangdong Food Green Processing and Nutrition Regulation Technology Research Center, Guangzhou 510640, China.
Food chemistry
|February 14, 2025
概括
化大豆蛋白纳米颗粒 (SNP) 具有特定的疏水负载模式,增强了维生素D3 (VD3) 的输送和吸收. 不同的加载策略显著影响了SNP结构,消化和释放特征,改善了营养物质的生物可用性.
科学领域:
- 食品科学与技术 食品科学与技术
- 纳米技术在营养中的应用
- 生物材料工程 生物材料工程
背景情况:
- 化大豆蛋白纳米粒子 (SNPs) 被探索为营养递送的载体.
- 维生素D3 (VD3) 提供效率对于其生物可用性和健康益处至关重要.
- 了解在消化过程中的纳米粒子行为是优化营养吸收的关键.
研究的目的:
- 调查不同VD3加载模式的SNP的传输效率.
- 评估不同SNP结构对VD3稳定和在消化过程中的释放的影响.
- 确定纳米粒子重塑如何影响细胞吸收和吸收VD3.
主要方法:
- 具有明显VD3负载模式的SNP的合成和表征 (模式1:疏水负载,模式2:联合组装).
- 在体外消化模型模拟胃和肠道条件.
- 分析纳米粒子结构变化,VD3释放动力学和细胞形成.
- 细胞吸收效率的评估.细胞吸收效率的评估.
主要成果:
- 具有疏水负荷的SNP (Pro1,Pro2) 显示出优异的稳定性和持续的VD3释放.
- 联合组装的SNP (Pro3) 由于结构不稳定,表现出较弱的保护和较快的VD3释放.
- 在消化过程中纳米颗粒的重塑,特别是疏水聚合,促进了持续释放,并通过混合细胞增强了吸收.
- 同时组装的纳米粒子在暴露于胆盐后立即脱离,导致VD3的快速释放.
结论:
- 将VD3纳入SNP的方法显著影响了消化过程中的载体结构和稳定性.
- 疏水性负荷模式对于持续的VD3释放和增强的吸收更有效.
- 纳米粒子重塑和消化行为是影响封装VD3的生物利用性的关键因素.
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