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暴露于制阻燃剂和动脉样硬化之间的关联:证据表明炎症状态作为潜在的调解者
Zihui Zhao1, Chi Zhang2, Yuanyuan Li3
1School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China.
The Science of the total environment
|February 14, 2025
概括
制阻燃剂 (BFR) 与动脉样硬化有关. 较高的BFR水平,特别是BB-153,增加动脉样硬化风险,炎症指标如白细胞和血小板作为关键介导体.
科学领域:
- 环境健康 环境健康
- 心血管科学 心血管科学
- 毒理学 毒理学 毒理学
背景情况:
- 制阻燃剂 (BFR) 是一种持久性,生物积累性化学物质,对其对心血管健康影响的研究有限.
- 动脉样硬化是一种重要的心血管疾病,了解其环境风险因素至关重要.
研究的目的:
- 调查暴露于特定BFR和动脉样硬化之间的关联.
- 探索炎症指标在BFR-动脉样硬化关系中的潜在调解作用.
主要方法:
- 利用了国家健康和营养检查调查 (2003-2004) 的1654名参与者的数据.
- 测量了六种BFR (BB-153,BDE-28,BDE-47,BDE-99,BDE-100,BDE-153) 和六种炎症指标的血清水平.
- 采用了统计分析,包括后勤回归,受限制的立方线,贝叶斯核机回归和调解分析.
主要成果:
- 在动脉样硬化组中发现BB-153,BDE-28,BDE-47,BDE-99和BDE-100的血清水平升高.
- 在BB-153和动脉样硬化之间观察到一个显著的,非线性,反转的U形关联.
- BB-153显示了与动脉样硬化最强的相关性 (OR = 2.059).
- 确定了一种剂量-反应关系,较高的BFR水平与增加的动脉样硬化风险相关.
- 白细胞计数和血小板水平被确定为BDE-153,BDE-100和动脉样硬化之间的联系的主要媒介.
结论:
- 暴露于特定的BFRs,特别是BB-153,与增加动脉样硬化风险有关.
- 由WBC和PLT水平显示的炎症状态,在BFR暴露和动脉样硬化发展之间的关系中起着调解作用.
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