癌症患者败血症的流行病学和预后:一个多中心前性观察性研究
Zeynep Ture1, Gülşen İskender2, Mustafa Serhat Şahinoğlu3
1Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, , Türkiye.
The American journal of the medical sciences
|February 14, 2025
概括
败血症影响9.1%的住院癌症患者,增加了他们的90天死亡率13倍. 关键的风险因素包括侵入性设备和抗生素耐药性,突出显示了对抗菌药物管理的必要性.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 败血症对癌症患者,一个脆弱的人群构成重大威胁.
- 了解败血症流行病学及其对癌症患者死亡率的影响对于改善结果至关重要.
研究的目的:
- 调查住院癌症患者中败血症的发病率,危险因素和预后影响.
- 确定败血症对癌症患者整体死亡率的影响.
主要方法:
- 一项多中心,前性,观察性研究,涉及790名没有败血症住院的癌症患者.
- 随访直到出院或90天以评估败血症发病率,危险因素和死亡率.
主要成果:
- 败血症发生在9.1%的癌症患者中. 风险因素包括年龄较大,感染住院,GVHD,导管使用和先前的细菌感染.
- 败血症显著增加了90天死亡率 (OR 13.42). 与败血症患者的死亡率相关的因素包括耐卡巴胺细菌感染,经验治疗的适当性以及到第5天的临床改善.
结论:
- 败血症在住院的癌症患者中很常见,并大大增加了死亡率.
- 侵入性设备,GVHD和先前感染是败血症风险因素;抗生素耐药性是死亡率的关键驱动因素.
- 对抗微生物药物的管理和对侵入性设备的明智使用对于减少癌症患者的败血症相关死亡至关重要.
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