与RSV相关的ARI住院的发生率,包括CAP:来自德国前性THEpiCAP研究的数据
Caihua Liang1, Elizabeth Begier2, Stefan Hagel3
1Pfizer Inc., New York, USA.
The Journal of infection
|February 14, 2025
概括
呼吸道同胞病毒 (RSV) 对老年人产生重大影响,导致严重的肺炎和其他呼吸道疾病. 这项研究强调了德国与RSV相关的高住院率和死亡率,强调了疫苗接种的必要性.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 呼吸道共囊病毒 (RSV) 是导致老年人急性呼吸道感染 (ARI) 的主要原因之一,包括社区获得性肺炎 (CAP).
- 现有的数据往往低估了与RSV相关的ARI住院病例的真实发生率.
- 这项研究旨在更准确地估计老年人RSV相关ARI住院发生率.
研究的目的:
- 估计德国成年人与RSV相关的ARI和CAP住院病例的发生率.
- 为了调整鼻/鼻抽样检测中RSV感染的不足检测.
- 评估老年人中的RSV负担,并为疫苗接种策略提供信息.
主要方法:
- 德国 (2021-2023) 成人CAP住院病例的前性监测.
- 在CAP患者的鼻/鼻抽样中进行RSV检测.
- 应用特定年龄比例和多样本研究数据来推断与RSV相关的ARI率.
主要成果:
- 调整后的与RSV相关的CAP每10万人住院率为18-59岁的4.9%,≥60岁的115.6.
- 调整后的RSV相关ARI每10万人的住院率为18-59岁的19.8%,≥60岁的401.6.
- 在RSV相关的CAP入院30天内,65岁以上的患者的死亡率为18.2%,老年人群有显著的心血管事件.
结论:
- 德国的老年人面临着与RSV相关的ARI和CAP住院治疗的重大负担.
- 这些发现强调了RSV在这个人口群体中的重大公共卫生影响.
- 高负担表明,RSV疫苗接种对老年成人人口可能具有高度的益处.
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