在肌肉侵入性膀癌中循环瘤DNA:系统性审查
A A Grosso1, A Cadenar1, S Pillozzi2
1Departamento de Medicina Experimental y Clínica, Universidad de Florencia; Unidad de Urología Oncológica y Andrológica Mínimamente Invasiva, Hospital Careggi, Florencia, Italy.
Actas urologicas espanolas
|February 14, 2025
概括
循环瘤DNA (ctDNA) 显示出作为预测肌肉侵入性膀癌 (MIBC) 结果的生物标志物具有前途. 它可以帮助指导术后治疗决策,但需要更多的研究.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
- 尿道瘤学 尿道瘤学
背景情况:
- 肌肉侵入性膀癌 (MIBC) 需要有效的生物标志物用于术后管理.
- 循环瘤DNA (ctDNA) 分析正在成为癌症研究中的非侵入性工具.
研究的目的:
- 评估ctDNA在MIBC的外科手术环境中的预后和预测价值.
- 评估ctDNA在指导治疗决策中的实用性,用于接受激进囊切除术和外科治疗的患者.
主要方法:
- 使用主要的生物医学数据库 (PubMed,MEDLINE,Embase) 进行了系统的文献审查,遵循PRISMA指南.
- 包括研究的重点是MIBC患者的ctDNA,这些患者接受了急性囊切除术 (RC) 与外科化疗或免疫疗法,发表于2013年1月至2024年3月之间.
主要成果:
- 八项研究表明,在急性囊切除前的ctDNA水平与较差的无复发生存率和晚期疾病相关.
- 在新辅助疗法期间,术后的ctDNA水平和ctDNA清除与无病存活率,复发率和治疗反应有关.
- 新辅助免疫治疗后ctDNA状态预测了病理结果和复发.
结论:
- ctDNA是一种有价值的生物标志物,用于预测MIBC患者的瘤结果.
- ctDNA有可能为MIBC的外科手术期治疗策略提供信息.
- 通过随机对照试验进行进一步验证对于确认这些发现和临床实用性至关重要.
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