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肝脏特异性CYP7B1的转基因表达减弱了早期西方饮食诱导的MASLD进展

Genta Kakiyama1, Nanah Bai-Kamara2, Daniel Rodriguez-Agudo1

  • 1Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Research Services, Central Virginia Veterans Affairs Health Care System, Richmond, VA, USA.

Journal of lipid research
|February 14, 2025
PubMed
概括

在小鼠中过度表达肝脏特异性氧化7α-基酶 (CYP7B1) 预防了西方饮食引起的肝毒性. 这突显了CYP7B1在通过控制氧积累来缓解代谢功能障碍相关的脂肪性肝病 (MASLD) 进展中的作用.

关键词:
CD36 CD36 CD36 CD36 CD36 CD36 CD36 CD36 CD36 CD36 CD36 CD36 CD36 CD36胆固醇 胆固醇 胆固醇 是一种这是一种炎症炎症炎症炎症.脂肪毒性 脂肪毒性 脂肪毒性肝脏 肝脏 肝脏 肝脏 肝脏 肝脏线粒体中的线粒体.氧化胆固醇是一种氧化醇.

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