内生菌 Umbelopsis sp. 的内生真菌 TM01作为Tricholoma matsutake的高活性替代品
Lu Hu1, Kun Dai2, Chenhui Gong2
1Sauvage Laboratory for Smart Materials, Harbin Institute of Technology, Shenzhen 518055, China; SHE LOG (Guangzhou) Biotechnology Co., Ltd, Guangzhou 510080, China.
Bioresource technology
|February 14, 2025
概括
一种内菌的真菌,Umbelopsis sp. 这是一种内菌. TM01,显示承诺作为一个可持续的替代品,罕见的Tricholoma松竹. 它的提取物 (UFE) 与较低的细胞毒性提供卓越的化品益处,使其成为化品行业的理想选择.
科学领域:
- 菌类学 菌类学是指菌类学.
- 生物技术是生物技术.
- 化品科学 化品科学
背景情况:
- 松竹是一种有价值但稀缺的化品和食品的资源,由于其营养含量和有限的生长.
- 由于T. matsutake的稀缺性,阻碍了它在工业领域的大规模应用.
- 内生菌提供了有价值的生物材料的潜在替代来源.
研究的目的:
- 从T. matsutake中分离和评估一种内菌,用于化品应用.
- 为了比较Umbelopsis sp.提取物的生物活性和安全性. TM01 (UFE) 与T.松竹提取物 (TME) 进行配合.
- 评估Umbelopsis sp.的潜力 评估Umbelopsis sp.的潜力 TM01作为T. matsutake在化品中的可持续替代品.
主要方法:
- 隔离的内性真菌 Umbelopsis sp. 的分离. 从T. matsutake的TM01获得的果实体.
- 提取和比较分析UFE和TME的生物活性 (抗铁酶,抗纹,伤口愈合).
- 在人类皮肤纤维细胞上对UFE的细胞毒性评估.
- 对UFE的代谢分析.
主要成果:
- 乌姆贝洛普西斯 (Umbelopsis sp.) 是一种植物. TM01成功地被分离和鉴定出来.
- 与TME相比,UFE表现出更高的生物活性,包括增强的抗铁酶和抗纹效应.
- UFE在伤口愈合方面表现出与TME相似的疗效.
- UFE显示出低细胞毒性,在10%度下对人类皮肤纤维细胞是安全的.
- 代谢分析表明UFE中存在各种各样的二次代谢产物.
结论:
- 乌姆贝洛普西斯 (Umbelopsis sp.) 是一种植物. TM01是一种有前途的内菌,对化品行业有很大的潜力.
- UFE可以作为T. matsutake的可行和可持续的替代品,提供可比或优越的化品效益.
- 紫外线的安全性和丰富的二次代谢物含量支持其在化品配方中的使用.
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