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针对肥胖的新兴药物疗法:系统性审查
Michail Kokkorakis1, Marlene Chakhtoura2, Caline Rhayem2
1Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Pharmacological reviews
|February 14, 2025
概括
新兴的肥胖药物治疗方法,特别是烯类型药物,显示出减肥的前景. 需要进一步研究长期影响,安全性和不同人群的可访问性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
- 临床试验 临床试验
背景情况:
- 肥胖是21世纪的主要流行病,有效的药物疗法有限.
- 历史上的抗肥胖药物通常具有低于最佳的疗效和安全性.
- 围绕肥胖的社会污名往往错误地将体重增加归因于意志力缺陷.
研究的目的:
- 系统地审查新型抗肥胖药物治疗的2期和3期临床试验.
- 将新兴治疗方法与安慰剂,对照剂或现有的FDA批准的药物进行比较.
- 确定肥胖治疗管道中的药物的当前状态和作用机制.
主要方法:
- 在Medline,Embase和ClinicalTrials.gov (2012-2024) 的系统文献搜索.
- 包括超重或肥胖的成年人的第二阶段和第三阶段试验.
- 对试验状态,药物机制和报告的疗效数据的分析.
主要成果:
- 确定了53项试验,评估了36种新药剂或组合.
- 口服赛马格卢提德50毫克是唯一完成第三阶段试验的药物.
- 目前正在进行的14项第三阶段试验涉及GLP-1受体激活剂和其他新机制,而第二阶段试验显示显著的体重减轻 (7.4%-24.2%).
结论:
- 肥胖药物管道正在迅速扩大,因克雷丁类类似物显示出最有前途的结果.
- 关于长期安全性,维持体重的有效性以及心脏-脏-代谢结果的进一步数据至关重要.
- 解决代表性不足的人口,成本效益和药物可用性是弥合肥胖症护理差距的关键.
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