早期发病的精神疾病与REM睡眠行为障碍的关联 - 一项回顾性研究
Connie Xie1, Aditii Makwana1, Helen Driver2
1Center for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Sleep medicine
|February 14, 2025
概括
与阻塞性睡眠呼吸暂停 (OSA) 患者相比,患有REM睡眠行为障碍 (RBD) 的患者表现出更高的早期精神疾病患病率. 这突显了RBD和精神疾病之间的潜在联系.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 雷姆睡眠行为障碍 (RBD) 是像帕金森氏症这样的神经退行性疾病的预测因素.
- 此外,RBD还与儿童的精神疾病有关,包括焦虑,抑郁和ADHD.
研究的目的:
- 分析RBD.转诊的患者中早期发病的精神疾病的患病率.
- 测试早期精神疾病在RBD患者中更常见的假设.
主要方法:
- 在金斯顿健康科学中心 (KHSC) 睡眠实验室进行了回顾性图表审查.
- 收集了关于睡眠研究,精神病诊断/症状,药物历史和神经退行性疾病的数据.
主要成果:
- 经过多梦诊断确认的RBD患者中,早期精神疾病的患病率为32%.
- 阻塞性睡眠呼吸暂停 (OSA) 控制组显示,这些疾病的患病率仅为3%.
结论:
- 早期发病的精神疾病在转诊RBD的患者中比在OSA对照中更为常见.
- 需要进一步的研究来验证和复制这些发现.
相关概念视频
REM Sleep Behavior Disorder
130
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
130
Narcolepsy
88
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
88
Sleep-Wake Cycles
1.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.2K
Sleepwalking and Sleep Talking
110
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
110
Oppositional Defiant Disorder
23
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Diagnostic Criteria and...
23
Nightmares and Night Terrors
71
Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares...
Nightmares...
71


