基于家族的Helicobacter pylori查及其益处的流行病学研究:一个横截面研究
Ao-Fei Huang1, Cong He1, Jian-Wen Sheng2
1Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yong Wai zheng Street, Donghu District, Nanchang, 330006, Jiangxi Province, China.
Scientific reports
|February 14, 2025
概括
对Helicobacter pylori (H. pylori) 感染的以家庭为中心的管理是有效的. 大家庭和父母感染增加了H. pylori的风险,而家庭成员的成功根除减少了传播,突出了加强家庭教育的需要.
科学领域:
- 传染病流行病学 传染病流行病学
- 家庭医学 家庭医学 家庭医学
- 公共卫生 公共卫生
背景情况:
- 杆菌 (H. pylori) 感染对健康构成重大风险.
- 了解家庭传播动态对于有效管理至关重要.
- 以前的研究还没有完全阐明以家庭为中心的风险因素和传播模式.
研究的目的:
- 调查家庭内H. pylori的传播动态,治疗坚持和风险因素.
- 评估以家庭为中心的方法在管理H. pylori感染中的有效性.
- 确定与H. pylori在家庭中的流行相关的关键人口和生活方式因素.
主要方法:
- 全国多中心H. pylori流行研究 (2021) 和随后的两年随访数据的回顾性分析.
- 包括中国江西省宜春市514个家庭的人口统计,生活方式和感染状况数据.
- 统计分析以确定各种风险因素的几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 较大的家庭规模 (≥5个人) 和较高的世代数量显著与增加的H. pylori感染风险相关 (例如,家庭规模>6:或4.46).
- 成年年龄,婚姻状况和现有的家庭成员感染 (母亲,父亲,兄弟姐妹) 被确定为H. pylori的主要风险因素.
- 在两个或两个以上的家庭成员中成功根除H. pylori,可以降低其他人的感染风险 (OR 0.25),这表明集群和家庭控制的潜力.
结论:
- H. pylori 在家庭中表现出显著的聚类,支持基于家庭的管理策略.
- 加强家庭对H. pylori危害的教育是必不可少的,因为目前的家庭管理实践的遵守程度不够理想.
- 家庭内有针对性的查和干预计划可以改善H. pylori感染控制.
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