抑制SUMOylation增强了葡萄糖皮质体受体的作用,以计划急性淋巴细胞白血病细胞的生长停止

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Updated: May 28, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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Emma Valima1, Vera Varis1, Kseniia Bureiko1

  • 1Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

Oncogene
|February 14, 2025
PubMed
概括

向SUMOylation增强了B细胞急性淋巴细胞白血病 (B-ALL) 的葡萄糖皮质体治疗. 抑制SUMOylation会增加葡萄糖皮质体受体的结合,抑制细胞生长基因,并提高B-ALL细胞和患者样本的治疗效率.

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