使用受约束的球形解卷在多扩散权重磁共振成像中的结构连接体构造
Marlene Tahedl1, J-Donald Tournier2,3, Robert E Smith4,5
1Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. marlene.tahedl@tum.de.
Nature protocols
|February 14, 2025
概括
本研究详细介绍了一种使用先进的扩散权重磁共振成像 (dMRI) 技术和软件工具生成高质量的结构连接组 (SC) 脑连接图的协议.
科学领域:
- 神经成像是一种神经成像.
- 计算神经科学是一种神经科学.
- 神经解剖学是一个神经解剖学.
背景情况:
- 结构连接组 (SC) 地图表是从体内扩散权重磁共振成像 (dMRI) 数据生成的.
- 基于网络的分析方法被采用为大脑连接研究.
研究的目的:
- 为生成高质量的脑连接SCs提供一个逐步的协议.
- 利用最近在dMRI数据处理和曲谱学方面的进展来提高生物准确性.
主要方法:
- 使用具有受约束球形解卷的多层dMRI数据,以提高纤维方向估计和组织信号的分离.
- 实施解剖学上受约束的轨迹学和球形解卷信息过的轨迹图,以提高轨迹学准确性.
- 使用MRtrix3软件实现协议,使用FSL软件执行特定的处理任务.
主要成果:
- 该协议可以生成高质量的SCs,对交叉纤维的敏感性增加,生物精度提高.
- 中间步骤可以适应相关分析,例如基于兴趣的区域曲谱学和局部白质物质性质量化.
结论:
- 本协议提供了一种标准化方法,用于创建精确的结构连接组图.
- 该程序适合具有dMRI和神经科学专业知识的用户,需要213小时的计算时间.
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