严重功能障碍的治疗患者的前景
Harald Aiff1,2, Per-Ola Attman3,4, Mihaela Golic3,5
1Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. harald.aiff@gu.se.
International journal of bipolar disorders
|February 14, 2025
概括
治疗可能导致功能显著下降,包括末期病 (ESRD). 仔细监测和与科的合作对于管理治疗功能下降的患者至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 是一种广泛使用的情绪稳定剂,具有已知的毒性潜力.
- 在治疗的患者中,进展到末期病 (ESRD) 需要仔细管理和考虑替代疗法 (RRT).
研究的目的:
- 调查长期结果和替代疗法 (RRT) 在治疗的患者中使用,这些患者患有末期病 (ESRD).
- 评估持续治疗对慢性病4期 (CKD4) 患者存活时间的影响.
主要方法:
- 对有过治疗史的成年患者的回顾性分析和估计的膜过率 (eGFR) <30毫升/分钟/1.73米2.
- 数据收集包括从1980年到2017年的生存率,并发症,治疗状态和RRT资格.
主要成果:
- 14%的治疗患者表现出EGFR<30毫升/分钟/1.73米2. 其中,25%进展为CKD4,5%需要RRT.
- 在CKD4诊断后,患者65岁以下的中位生存时间为13.9年,老年患者为4.4年.
- 在CKD4患者中,持续的治疗与停止治疗的患者相比,生存率没有显著差异.
结论:
- 在接受治疗的患者中,功能显著下降 (eGFR <30毫升/分钟/1.73米2),需要密切的脏监测.
- 虽然一些功能损失是暂时的,但相当一部分会发展为慢性病或急性功能衰竭.
- 适当的护理,包括RRT,可以确保几年后功能衰竭的生存,强调精神病学和学合作的重要性.
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