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在神经元特定的Pten淘汰赛小鼠中,通过mTOR抑制的表型救援揭示了AKT和mTORC1位点特定的变化

Angelica D'Amore1, Maria Sundberg1, Rui Lin1

  • 1Department of Neurology, FM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, USA.

Molecular psychiatry
|February 14, 2025
PubMed
概括

在PTEN Hamartoma瘤综合征 (PHTS) 的新型小鼠模型中,药理性mTOR抑制与everolimus部分挽救了神经缺陷. 治疗改善了生存率,并挽救了突触和网络过活性,揭示了PHTS相关的神经发育障碍的治疗潜力.

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