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基于登记册的研究中,低水平空气污染与出生体重的关联:潜在的影响低于世卫组织QA指导方针

Isabell K Rumrich^1,2,3, A Korhonen^4,5, B Forsberg⁶

¹Finnish Institute for Health and Welfare, Department of Public Health, Kuopio, Finland. isabell.rumrich@thl.fi.

BMC pregnancy and childbirth

|February 14, 2025

概括

母亲暴露于空气污染,即使在低水平,也与降低出生体重有关. 这项研究发现,对于PM2.5等污染物,没有安全暴露值,这突出了公众健康的担忧.

科学领域:

环境健康环境健康
生殖流行病学生殖流行病学
公共卫生公共卫生

背景情况:

怀孕期间暴露于空气污染与不良分娩结果有关.
对于非常低暴露水平的影响存在不确定性.
这项研究调查了低水平空气污染物暴露对出生体重的影响.

研究的目的:

探索怀孕期间母亲暴露在极低水平的空气污染物和出生体重之间的关系.
估计空气污染对出生体重的公共卫生影响.

主要方法:

使用了MATEX出生队列 (226,551个出生).
在怀孕期间在家庭地址与八种模拟空气污染物 (PM2.5,PM10,PM粗,NO2,NOx,CO,SO2,O3) 相关联的队列数据.
使用多重回归来估计出生体重的变化,并量化了与PM2.5.5相关的潜在低出生体重病例.

主要成果:

颗粒物 (PM2.5,PM粗,PM10) 显示出出生体重的最大减少.
气体污染物 (NO2,CO,NOx,SO2) 也与降低出生体重有关,而NO2具有最强的影响.
观察到对出生体重的影响甚至低于世卫组织指导值,PM2.5暴露相当于平均暴露时的30g损失.

结论:

没有确定怀孕期间空气污染物暴露的安全水平.
除臭氧外,所有研究的污染物都与降低出生体重有关.
因果关系和混需要在未来的研究中进一步关注.

关键词:

空气污染大气污染出生的体重出生时的体重.低出生体重低出生体重怀孕怀孕怀孕怀孕在产前,产前生育.登记登记研究研究

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