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循环RNA APP通过通过miR-1906/CLIC1轴调节微质极化,有助于阿尔茨海默病的发病

Deng-Pan Wu^1,2, Yan-Su Wei¹, Li-Xiang Hou¹

¹Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Pharmacy School, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.

Alzheimer's research & therapy

|February 14, 2025

概括

这项研究确定了circAPP,一种新型的循环RNA,作为阿尔茨海默病 (AD) 发病过程中的关键调节者. CircAPP通过miR-1906/CLIC1通路影响微质偏振,为AD提供了潜在的治疗点.

科学领域:

神经科学是一个神经科学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

异常的微质两极分化与阿尔茨海默氏症 (AD) 病原发生有关.
循环RNAs (circRNAs) 在人类疾病中起着重要作用,它们在AD中的特定功能在很大程度上尚未被探索.

研究的目的:

为了识别和描述参与AD病变发生的新型circRNAs.
阐明circAPP在微质极化和AD进展中的功能作用.

主要方法:

在AD小鼠模型中,circRNA微阵列分析确定了差异表达的circRNA.
生物信息学和蛋白质组学确定了circAPP的目标miR-1906和CLIC1.
行为测试,分子测试和基于细胞的实验评估了AD中的circAPP功能.

主要成果:

一个由APP编码的新型circRNA,circAPP,在AD模型中被上调.
循环APP通过miR-1906/CLIC1轴调节微质M1/M2极化.通过miR-1906/CLIC1轴调节微质M1/M2极化.通过miR-1906/CLIC1轴调节微质M1/M2.
调节circAPP,miR-1906,或CLIC1改善了小鼠的AD病理和认知功能.

结论:

通过调节微质极化,CircAPP在AD病变发生过程中发挥着至关重要的作用.
环APP/miR-1906/CLIC1轴代表了阿尔茨海默病的潜在治疗点.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.在 CLIC1 中使用.微质的极化是微质的极化环RNA 环RNA 是一个环RNA.在 miR-1906 中使用.

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