在初级保健中基于互联网的认知行为疗法的治疗效果的个体差异:随机临床试验的适度分析
Karin Hyland1,2, Danilo Romero3,4, Sven Andreasson3,5,4
1Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. karin.hyland@ki.se.
Addiction science & clinical practice
|February 14, 2025
概括
依赖程度预测了初级保健中酒精依赖的治疗结果. 患有严重依赖症的患者最初显示酒精消费减少更大,而中度依赖症随着时间的推移而改善.
科学领域:
- 药物中毒药物 药物中毒药物
- 初级保健研究初级保健研究
- 数字健康干预措施 数字健康干预措施
背景情况:
- 在初级保健中,对于酒精依赖的治疗结果的预测因素尚不清楚.
- 基于互联网的认知行为治疗 (ICBT) 结合常规治疗 (TAU) 是治疗酒精依赖的潜在方法.
- 研究影响治疗成功的因素对于优化护理至关重要.
研究的目的:
- 检查社会人口统计学和临床因素预测患者接受ICBT加TAU治疗酒精依赖的结果.
- 为了确定酒精消费变化的预测因素和治疗效果的调节者.
主要方法:
- 一项随机对照试验的二次分析,涉及264名成年初级保健患者的酒精依赖.
- 参与者被随机分配到ICBT + TAU或单独TAU.
- 用过去30天的标准饮料数量来评估结果,并通过线性混合效应模型分析预测因素.
主要成果:
- 酒精依赖的严重程度是酒精消费变化的唯一预测因素,也是治疗效果的调节者.
- 与中度依赖患者相比,严重依赖患者最初的酒精消费减少更大.
- 虽然中度依赖患者在12个月内继续减少消费,但严重依赖患者在3个月后没有进一步改善.
结论:
- 依存症的严重程度是影响初级保健治疗中酒精消费变化的关键因素,无论增加了ICBT.
- 治疗的有效性因依赖程度的严重程度而受到缓解,这表明定制方法可能是有益的.
- 这些发现支持在初级保健机构内治疗中度和重度酒精依赖的可行性.
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