在脏重症监护病房的多器官功能障碍综合征患者中,持久性淋巴缺血作为预后不良因素:一项回顾性单中心研究
Xiang Xue1, Shuhua Zhu1, Shutian Xu1
1National Clinical Research Center of Kidney Disease, Nanjing Medical University, Jingling Hospital, Nanjing, China.
Immunity, inflammation and disease
|February 15, 2025
概括
在科重症监护室的多器官功能障碍综合征 (MODS) 与高死亡率有关. 持续的淋巴缺血,尤其是严重的淋巴缺血,显著增加了28天死亡风险. 淋巴细胞数量在第7天预测预后.
科学领域:
- 关键护理医学 关键护理医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
背景情况:
- 多器官功能障碍综合征 (MODS) 是一种严重的疾病,死亡率高.
- 具体在脏重症监护室 (ICU) 设置中的MODS临床数据有限.
- 了解脏ICU患者的MODS对于改善结果至关重要.
研究的目的:
- 调查MODS患者的临床特征,这些患者被录入脏ICU.
- 确定预后,并确定这种患者群体中死亡率的风险因素.
- 探索淋巴细胞减小和脏ICU患者MODS的结局之间的关联.
主要方法:
- 进行了一项回顾性队列研究,涉及99名接受脏ICU治疗的成年患者.
- 数据是在2011年10月1日至2021年10月1日期间在一个单一中心收集的.
- 分析了临床特征,疾病严重程度 (APACHE-II评分) 和淋巴细胞计数.
主要成果:
- 感染,特别是肺部感染,在80.8%的患者中是入院的主要原因.
- 在73.7%的患者中观察到持续性淋巴细胞衰竭,严重的淋巴衰竭与显著更高的28天死亡率 (87.5%) 相关.
- 28天死亡率的独立风险因素包括受影响的器官数量,APACHE-II评分和持续性淋巴缺血症. 第7天的淋巴细胞计数显示出高预测值 (AUC=0.831).
结论:
- 患有MODS的患者在脏重症监护室面临危急疾病和高死亡率.
- 持续性淋巴缺血是一种常见的发现,也是28天死亡率的独立预测因素.
- 第7天的淋巴细胞计数作为脏ICU中MODS患者的强有力的预后指标.
相关概念视频
Disorders of Leukocytes
837
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
837
Secondary Lymphoid Organs
1.1K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.1K


