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Updated: May 27, 2025

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
07:51

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

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一个全面的CYP2D6药物-药物-基因相互作用网络,用于精确剂量和药物开发

Simeon Rüdesheim1,2, Helena Leonie Hanae Loer1, Denise Feick1,3

  • 1Clinical Pharmacy, Saarland University, Saarbrücken, Germany.

Clinical pharmacology and therapeutics
|February 15, 2025
PubMed
概括

基于生理学的药理动力学 (PBPK) 建模网络可以预测复杂的药物-药物-基因相互作用 (DDGIs),帮助临床剂量建议. 这项研究开发了CYP2D6的PBPK网络,证明了其用于精确剂量的潜力.

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A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

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Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures

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