从STEP-BD队列中对并发性双极性障碍和创伤后应激障碍的药物治疗
Samantha E Russell1,2, Anna L Wrobel1,3,4, David R Skvarc1,4
1Deakin University, School of Medicine, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, Geelong, Australia.
Bipolar disorders
|February 15, 2025
概括
患有双相情感障碍 (BD) 和创伤后应激障碍 (PTSD) 的个人经历了更糟糕的症状和结果. 对这种并发症的治疗考虑对于改善患者福祉至关重要.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 创伤后应激障碍 (PTSD) 在双相情感障碍 (BD) 群体中非常普遍.
- 有限的研究存在于BD和PTSD并发症的药物治疗.
研究的目的:
- 探索在BD和并发性BD/PTSD中的基线药物治疗模式.
- 评估这些治疗对24个月的症状的影响.
主要方法:
- 使用了BD (STEP-BD) 队列的系统治疗增强计划.
- 比较单独使用BD的BD症状和药物治疗 (n=3393) 与BD/PTSD (n=304).
- 使用回归模型分析抑郁症,躁狂症,功能和生活质量.
主要成果:
- 在BD/PTSD组中,较低的使用,较高的抗抑郁药,抗精神病药和二使用.
- bensodiazepine 使用与轻微抑郁症的改善有关,但在并发病病例中生活质量较差.
- 伴并发性PTSD组显示出更高的躁狂/抑郁和更低的功能/生活质量,无论药物治疗.
结论:
- 伴并发性BD和PTSD与24个月的更糟糕的结果有关,独立于基线药物治疗.
- 强调需要在BD治疗中解决并发症.
- 对并发性BD/PTSD有效治疗策略的进一步研究是有必要的.
关键词:
双相情感障碍是双相情感障碍的一种疾病.抑郁 抑郁症 抑郁症 抑郁症 是一种疯狂的疯狂是什么意思心理健康 心理健康药物治疗药物治疗创伤后应激障碍 创伤后应激障碍精神病学是一种精神病学.一个创伤的创伤创伤.更多相关视频
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