相关实验视频

Updated: May 27, 2025

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

在治疗前和治疗后,双极性障碍患者的前-双极和语言网络连接及其与基因表达特征的关联

Leyi Zhang¹, Haohao Yan¹, Chunguo Zhang²

¹Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

CNS neuroscience & therapeutics

|February 15, 2025

概括

双极性障碍 (BD) 显示了前-双极 (FPN) 和语言网络 (LN) 中大脑连接的改变. 治疗减少了一些FPN-LN连接,表明这些网络是BD的关键.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
遗传学是一个遗传学.

背景情况:

在双相情感障碍 (BD) 中的休息状态功能连接 (FC) 仍然不清楚.
在BD中,前端-平行网络 (FPN) 和语言网络 (LN) 的特定模式需要进一步研究.

研究的目的:

在BD患者的FPN和LN中识别异常的FC模式.
为了检查这些FC模式在治疗后如何变化.

主要方法:

从82名BD患者和88名健康对照 (HC) 获得的静止状态成像和临床数据.
利用基于种子的FC分析和全脑回归来将FC与临床变量相关联.
进行了神经成像-转录空间关联分析.

主要成果:

在基线,BD患者表现出增加的FPN-LN和FPN-前额回形连接性.
在LN和thalamus,直角环 (AG) 和右小脑之间观察到超连接性.
三个月的治疗导致FPN与左STG,左SFG,左insula和双边MTG的连接性下降.

结论:

改变的FPN和LN FC模式与BD的病理生理学和治疗反应有关.
确定了与BD.中的功能障碍相关的潜在遗传途径.

关键词:

艾伦人类大脑图谱艾伦人类大脑图谱双相情感障碍是双相情感障碍的一种疾病.前端-平面网络的前端-平面网络功能连接性的功能连接性功能性磁共振成像技术功能性磁共振成像技术语言网络语言网络

更多相关视频

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

相关概念视频

Bipolar Disorder

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

Language and Cognition

Language and Cognition

Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.

Lateralization

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.