超重/肥胖和FTO基因多态性对中国青少年肝功能相关参数的影响
Meiwei Ning1, Aohong Xu2, Rong Zeng3
1Department of Laboratory Medicine, Heilongjiang University of Chinese Medicine Jiamusi College, Jiamusi, 154007, China.
The National medical journal of India
|February 15, 2025
概括
FTO基因 rs9939609 变体与中国青少年的超重/肥胖有关. 这种遗传变异与AST和ALT等较高的肝酶有关,突出显示肥胖症.
科学领域:
- 遗传学和新陈代谢
- 公共卫生与营养
背景情况:
- 超重和肥胖是肝病的重要危险因素,影响肝功能参数.
- 脂肪质量和肥胖相关 (FTO) 基因与肥胖和肝脏脂肪代谢之间的关系有关.
研究的目的:
- 调查FTO rs9939609基因变异与中国青少年肝功能参数之间的关联.
- 研究FTO rs9939609变体在年轻成年人中超重/肥胖症中的作用.
主要方法:
- 在198名对照和173名超重/肥胖的中国青少年 (16-26岁) 中,使用桑格测序对FTO rs9939609多态的基因定型.
- 分析肝功能参数,包括阿斯巴酸胺酶 (AST),氨酸胺酶 (ALT),玛-胺转移酶 (GGT) 和性酸酶 (ALP).
主要成果:
- 与对照组相比,超重/肥胖个体的AST,ALT,GGT和ALP水平显著更高.
- 与TT基因型相比,rs9939609 AA基因型与超重/肥胖的风险增加了3.45倍,独立于BMI.
- FTO rs9939609 AA基因型显示出与升高的AST和ALT水平有显著的正相关性.
结论:
- FTO rs9939609变种与中国青少年的超重/肥胖有显著的相关性.
- 超重/肥胖状态强烈影响肝功能参数的增加,特别是AST和ALT.
- 具有FTO rs9939609 AA基因型的个体需要对肝功能进行警监测,因为AST和ALT的升高.
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