在精神分裂症患者中白质微观结构的半球不对称性,持续的听觉语言幻觉
Jinguang Li1,2, Jingqi He3, Honghong Ren1,4
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Furong District, Changsha 410011, Hunan, China.
精神分裂症患者患有持续的听觉语言幻觉,表现出改变的白质不对称性,特别是在上纵向囊中. 这种半球不对称性与幻觉的严重程度有关,这表明它在精神分裂症中的作用.
科学领域:
- 神经成像是一种神经成像.
- 精神分裂症研究 精神分裂症研究
- 大脑解剖学 大脑解剖学
背景情况:
- 听觉语言幻觉 (AVH) 是精神分裂症的一个核心症状.
- 与AVH相关的白质结构中半球不对称性的作用尚不清楚.
- 需要进行神经成像研究,以探索精神分裂症患者的白质不对称性.
研究的目的:
- 为了研究精神分裂症患者的白质不对称性,持续的听觉语言幻觉 (AVHs) 与没有AVHs和健康对照者相比.
- 检查白质不对称与AVH严重程度之间的关系.
- 为了确定白质不对称模式是否有助于AVH严重程度的变异.
主要方法:
- 分析了52名持续性AVH患者,33名从未经历过AVH患者和40名健康对照者的扩散张力成像 (DTI) 数据.
- 分数异构 (FA),轴向扩散 (AD),辐射扩散 (RD) 和平均扩散 (MD) 的不对称性指数 (AI) 为全脑白质骨架和22个感兴趣区域 (ROI) 计算.
- 使用回归来评估白质不对称对AVH严重性的贡献.
主要成果:
- 与健康对照组和从未患有AVH的组相比,持久性AVH组在全脑白质骨架中表现出减少的FA AI.
- 投资回报率分析显示,在持续性AVH组中,FA AI在9对中降低,MD AI在2对中增加.
- 上面纵向 (SLF) 的右侧不对称性与AVH严重程度的增加相关,SLF FA AI改善了AVH严重程度的预测.
结论:
- 在精神分裂症患者中存在明显的白质不对称模式,患者有持续的AVH.
- 半球不对称性,特别是涉及SLF,在精神分裂症中AVH的病理生理学中起着重要作用.
- 这些发现提供了新的神经成像证据,将白质结构不对称与听觉语言幻觉联系起来.
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