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Updated: May 27, 2025

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
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在儿科急性淋巴细胞白血病中高剂量甲状腺素诱导毒性的剂量调整策略:基于人群PK分析和暴露毒性关系

Ailing Cao1, Yanping Guan1, Jian Wang2

  • 1Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong Province, China.

Cancer chemotherapy and pharmacology
|February 15, 2025
PubMed
概括

对急性淋巴细胞白血病 (ALL) 的高剂量甲状腺素 (HD-MTX) 治疗可能会导致严重的毒性. 根据患者特定的MTX C24h和AUC0-24h水平来个性化HD-MTX剂量,可以显著改善安全性和临床结果.

关键词:
急性淋巴细胞白血病 (Acute Lymphoblastic Leukemia) 是一种急性淋巴细胞白血病.剂量调整剂量调整高剂量的甲基甲酸盐.药理动力学 药理动力学

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