全球纵向菌株评分预测多发性硬化症患者的亚临床心脏参与
Fidel Demir1, Mehmet Özbek2, Mehmet Ata Akıl2
1Department of Neurology, Selahaddin Eyyubi State Hospital, Diyarbakır, Turkey. fideldemir2605@gmail.com.
概括
多发性硬化症 (MS) 患者表现出左心室全球纵向应变 (GLS) 的减少,表明亚临床心脏功能障碍. 这种心脏影响随着MS严重程度的增加而恶化,根据EDSS得分进行测量.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 多发性硬化症 (MS) 与心血管疾病的风险增加有关.
- 关于MS中心血管并发症的数据有限.
- 应变心力回声学提供了对左心室 (LV) 缩功能的客观评估.
研究的目的:
- 用全球纵向菌株 (GLS) 来评估MS患者的LV功能.
- 调查GLS与MS疾病严重程度 (EDSS分数) 之间的关系.
主要方法:
- 80名RRMS患者和65名对照者的回顾性比较.
- 应变回声心力学被用来通过GLS评估LV静脉缩功能.
- 排除标准包括其他慢性疾病和最近恶化的治疗.
主要成果:
- 与对照组相比,MS患者的GLS显著降低 (-17.05 ± 1.33对比 -18.99 ± 1.08,p < 0.001).
- 较低的GLS得分与较高的EDSS得分相关 (r = -0.245,p = 0.003),表明在更严重的MS中心脏功能较差.
- 一个最佳的GLS切断值 (≤-17.10) 预测了MS患者的LV功能不佳.
结论:
- 应变回声心力学,特别是GLS,可以检测多发性硬化症患者的亚临床心肌功能障碍.
- 增加MS严重程度 (更高的EDSS) 与更大的亚临床心脏功能障碍有关.
相关概念视频
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Endocarditis III: Medical Management
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Heart Failure IV: Classification and Diagnostic Evaluation
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...


