一天两次还是一次? 菲尔格拉斯蒂姆剂量表用于外围造血干细胞调动
Mehmet Bakırtaş1, Bahar Uncu Ulu2, Tuğçe Nur Yiğenoğlu2
1Department of Hematology, Republic of Turkey Ministry of Health Tekirdağ Dr. İsmail Fehmi Cumalıoğlu City Hospital, Tekirdağ, Turkey.
Hematology, transfusion and cell therapy
|February 15, 2025
概括
每天服用一剂菲尔格拉斯蒂姆 (颗粒细胞殖民地刺激因子) 对健康捐赠者的造血干细胞动员同每天分两次剂量一样有效. 这一发现简化了G-CSF的管理协议.
科学领域:
- 血液学 血液学 血液学
- 干细胞生物学 干细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 颗粒细胞殖民地刺激因子 (G-CSF) 对于造血干细胞 (HSC) 调动至关重要.
- 目前的临床实践往往涉及每天分割G-CSF剂量,而一些中心使用单次每日管理.
研究的目的:
- 为了评估不同的filgrastim剂量表对HSC收集效率的影响.
- 为了比较每天一次和每天两次的G-CSF给药对干细胞调动的疗效.
主要方法:
- 一项对251名健康捐赠者进行的回顾性研究,这些捐赠者正在接受HSC调动.
- 捐赠者每天接受一次 (10毫克/公斤/天) 或每天两次 (5毫克/公斤/天两次) 的filgrastim.
- 对外围血液干细胞产量的比较和非的要求.
主要成果:
- 每天两次使用菲尔格拉斯导致白细胞和CD34+细胞数量在第5天显著增加.
- 在第一个非日收集的CD34+细胞数量中没有观察到显著差异.
- 达到目标CD34+细胞计数所需的阿菲雷斯手术的数量在各组之间没有显著差异.
结论:
- 一次每日10毫克/公斤的费尔格拉斯蒂姆剂量在治疗上相当于每天两次的分剂量,以便在健康的捐赠者中获得足够的CD34+细胞产量.
- 将G-CSF剂量计划简化为每天一次是HSC动员的一个可行的选择.
相关概念视频
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Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
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