线虫分泌的蛋白质家族调节宿主免疫力
Florent Colomb1, Henry J McSorley1
1Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.
Current opinion in microbiology
|February 15, 2025
概括
寄生性线虫分泌蛋白质以逃避宿主免疫力. 肠道线虫中的三个关键蛋白质家族抑制免疫反应,可能是潜在的疫苗点.
科学领域:
- 免疫学 免疫学 免疫学
- 寄生虫学的寄生虫学
- 分子生物学分子生物学
背景情况:
- 寄生性线虫在分泌/分泌 (E/S) 产品中使用免疫调节蛋白来逃避宿主防御.
- 这些E/S产品含有多种不同的蛋白质家族,有些是跨物种保存的,有些是独一无二的.
- 尼马E/S蛋白质向各种宿主分子,包括蛋白质,脂质,甘氨酸和代谢物.
研究的目的:
- 审查在肠道线虫中扩展的三个突出的免疫调节蛋白家族:毒液过敏原类蛋白质,apyrases和补充控制蛋白质域含有蛋白质.
- 讨论这些蛋白质抑制宿主免疫反应的机制.
- 突出这些蛋白质作为针对寄生虫线虫的疫苗抗原的潜力.
主要方法:
- 文献综述侧重于寄生性线虫的免疫调节蛋白.
- 在肠道线虫中扩展的蛋白质家族的分析.
- 检查免疫抑制机制和疫苗潜力的证据.
主要成果:
- 毒素过敏原类蛋白质,apyrases和补充控制蛋白质域含有蛋白质是肠道线虫中的关键免疫调节剂.
- 这些蛋白家族有效地抑制宿主免疫反应,有助于寄生虫的生存.
- 越来越多的证据表明,这些蛋白质可以作为有效的疫苗抗原.
结论:
- 特定的线虫E/S蛋白家族在免疫逃避中发挥着关键作用.
- 了解这些免疫调节蛋白,可以了解宿主-寄生虫相互作用.
- 这些蛋白质代表了开发针对寄生虫线虫感染的新型疫苗的有希望的候选人.
相关概念视频
02:47Protein Families
15.2K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key...
15.2K
02:26Conservation of Protein Domains Over Different Proteins
10.7K
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
10.7K
02:26NF-κB-dependent Signaling Pathway
7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.2K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
01:23Antimicrobial Proteins
873
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
873