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相关概念视频

REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

130
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
130
Narcolepsy01:07

Narcolepsy

88
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
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Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
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Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

131
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
131
Stages of Sleep01:22

Stages of Sleep

166
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
166
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

1.6K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
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相关实验视频

Updated: May 27, 2025

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
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Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

801

雷姆睡眠行为障碍的损伤网络映射

H Odd1, C Dore1, S H Eriksson2

  • 1Functional Imaging Laboratory, Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, UK.

NeuroImage. Clinical
|February 15, 2025
PubMed
概括

快速眼动睡眠行为障碍 (RBD) 与干脑损伤有关,这些损伤会扰乱睡眠. 这项研究确定了脑干脱节综合征,表明沿特定白质通道的损伤导致RBD,解释了疾病的变异性.

关键词:
阿尔法-同核素 疾病 疾病减退网络绘制地图莱维体疾病 莱维体疾病进行元分析分析.概率论的卷轴学可能论.雷姆睡眠行为障碍 睡眠行为障碍

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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相关实验视频

Last Updated: May 27, 2025

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06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

801
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科学领域:

  • 神经科学是一个神经科学.
  • 睡眠医学 睡眠医学
  • 神经学 神经学

背景情况:

  • 雷姆睡眠行为障碍 (RBD) 涉及雷姆睡眠期间肌肉的丧失,导致梦想的演变.
  • 异常性RBD是未来的α-synucleinopathies (如帕金森病) 的重要危险因素.
  • 人类RBD的精确神经解剖学基础尚未完全被理解,尽管动物研究确定了参与睡眠的脑干结构.

研究的目的:

  • 使用病变网络映射实证地定义RBD的候选解剖网络.
  • 测试RBD是由于对特定脑干节点,它们的白质连接或其他大脑区域的损伤而产生的假设.
  • 为了确定关键的大脑干区域和通道,参与维持REM睡眠.

主要方法:

  • 审查了二次RBD与离散脑损伤的已发表病例,以创建损伤面具 (n=25).
  • 在没有RBD的情况下使用MRI损伤口罩 (n=15) 作为排除口罩.
  • 采用了病变网络映射,概率曲谱和对人类连接组数据集的扭曲来识别和描述RBD网络.

主要成果:

  • 与RBD相关的病变主要位于脑干,具有显著的变异性.
  • 72%的RBD病变直接与白质通道相交,这些通道来自意义上的点区域 (ROI),重叠着点.
  • 92%的病变是在最大重叠区域或尾部,这表明连接正面位置和中枢骨髓的关键通道.

结论:

  • RBD似乎是一种脑干脱节综合征,其中损伤连接正面位置 (coeruleus) 和脑髓的通道会损害睡眠无力.
  • 这种模型与动物文献一致,可能解释神经影像检测结果的变异性和异常性RBD的临床表现.
  • 了解这个网络可以了解RBD的病理生理学及其与α-synuclein疾病的关联.