多发性硬化症中的光学连贯性断层扫描和血管学:系统性审查和元分析
Angeliki Filippatou1, Aikaterini Theodorou2, Maria-Ioanna Stefanou3
1Second Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Department of Neurology, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Journal of the neurological sciences
|February 15, 2025
概括
光学连贯断层扫描 (OCT) 可靠地量化了多发性硬化症 (MS) 中的视网膜神经轴损伤. 本综述综合了OCT和OCT血管学发现,确定了检测多发性硬化症患者视神经干扰的门.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 前视通路损伤在多发性硬化症 (MS) 中很常见.
- 光学连贯断层扫描 (OCT) 评估视网膜神经纤维层 (pRNFL) 和质细胞内状层 (GCIPL) 厚度.
- 通过OCT血管造影 (OCTA),可视化视网膜微血管结构.
研究的目的:
- 系统地审查和综合MS患者的OCT和OCTA发现.
- 为了比较视网膜结构和血管在MS患者和没有光神经炎 (ON) 与健康的对照 (HC).
- 评估OCT的诊断产量,以检测MS中单边视神经参与的情况.
主要方法:
- 在MS患者中使用OCT和OCTA的研究的系统审查和元分析.
- 包括的比较:MS-ON与HC,MS非ON (MS-NON)与HC,以及MS-ON与MS-NON.
- 分析了pRNFL,GCIPL,内核层 (INL) 厚度和视网膜血管密度.
主要成果:
- 分析包括170个OCT研究 (8542个HC,5529个MS-ON,14822个MS-NON眼睛) 和24个OCTA研究 (1344个HC,505个MS-ON,1168个MS-NON眼睛).
- 与HC相比,MS-ON和MS-NON眼睛的pRNFL和GCIPL厚度降低,外皮皮质和黄斑表面血管密度较低.
- 在HC和MS之间,INL厚度没有差异,但在MS-ON眼睛中比MS-NON眼睛更大.
结论:
- 通过OCT可可靠量化视网膜神经轴突损伤在MS.
- 海外国家和地区的研究结果可以为检测MS中单边视神经干扰的强大值.
- 海外和东欧国家和地区是评估MS相关视觉通路损伤的宝贵工具.
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