南亚的炎症性肠病:一个范围审查
Shabari Shenoy1, Anuraag Jena2, Carrie Levinson3
1Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; South Asian IBD Alliance, New York, NY, USA.
The lancet. Gastroenterology & hepatology
|February 15, 2025
概括
炎症性肠病 (IBD) 在南亚正在增加,男性的诊断率更高. 虽然治疗方法与西方国家相似,但迫切需要更多的研究和资源来应对这个日益严重的健康挑战.
科学领域:
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 的发病率和流行率正在南亚迅速上升.
- 在该地区,IBD的综合数据严重缺乏.
- 在全球范围内,IBD影响南亚移民,突出地区和民的影响.
研究的目的:
- 对南亚IBD的所有观察和干预研究进行范围审查.
- 总结有关该地区IBD流行病学,自然史,表型,治疗方法和心理健康的当前知识.
- 确定关键的知识差距和未来研究和干预的领域.
主要方法:
- 对南亚IBD的观察和干预研究进行系统的文献搜索.
- 从最初的14,924项研究中,包括了524项研究.
- 跨领域的研究结果的总结:流行病学,自然史,表型,并发症,治疗学和心理健康.
主要成果:
- 南亚IBD发病率和流行率不断上升,男性的诊断率更高.
- 遗传倾向是关键的风险因素;环境因素仍然不清楚.
- 延迟诊断是常见的,并且与更糟糕的结果有关;IBD表型和严重程度与西方地区相似.
- 皮质类固醇和免疫调节剂是主要的治疗方法;生物药物不太常见.
- 心理健康问题,营养不良和生活质量下降是普遍存在的.
- 补充和替代医学的使用值得注意.
结论:
- 在南亚,IBD是一个越来越大的挑战,需要紧急的临床和研究关注.
- 存在重大知识差距,特别是在印度以外的国家的数据和前性研究方面.
- 加强资源配置和卫生政策实施对于该地区的IBD管理至关重要.
相关概念视频
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
159
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
159
01:30Inflammatory Bowel Disease II: Crohn's Disease
205
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
205
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
328
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
328
01:17Chronic Bowel Disorders: Introduction
414
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
414
01:29Inflammatory Bowel Disease IV: Pharmacological Management
122
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
122
01:21Inflammatory Bowel Disease V: Surgical Management
133
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
133