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Updated: May 27, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
在急性高空暴露期间身体成分的变化与急性山病有关
Simin Zhou1, Huaping Dong1, Pei Huang1
1Department of High Altitude Operational Medicine, College of High Altitude Military Medicine, Army Medical University, Chongqing, 400038, China; Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Chongqing, 400038, China; Key Laboratory of High Altitude Medicine, PLA, Chongqing, 400038, China.
急性山病 (AMS) 与高海拔地区的身体组成变化有关. 无脂肪质量和体液的减少与AMS的严重程度和疲劳相关.
科学领域:
- 高度生理学 高度生理学
- 人类生理学 人类生理学
- 运动医学运动医学
背景情况:
- 急性缺氧暴露会引发急性山病 (AMS) 并改变身体组成.
- 身体组成变化和AMS之间的关系尚不清楚.
研究的目的:
- 为了评估高海拔地区的身体成分变化.
- 确定人体组成与AMS发生率和严重程度之间的关系.
主要方法:
- 在300米和3680米处监测了81名受试者.
- 测量了身体成分,并每天评估AMS发生情况,使用Lake Louise评分 (LLS) 系统六天.
主要成果:
- 在高海拔地区观察到体重,无脂肪质量 (FFM),体液总量 (TBW),细胞内水 (ICW),细胞外水 (ECW) 和细分瘦质量显著下降.
- 脂肪量 (FM) 增加,而矿物质含量显示过渡性变化.
- FFM,TBW和ECW的下降与LLS分数呈正相关,疲劳与FFM,TBW,ICW和ECW的下降有关.
结论:
- 早期高空暴露会导致显著的身体组成变化.
- 减少FFM,TBW和ECW可能与AMS严重程度有关.
- 疲劳与FFM,TBW,ICW和ECW的下降有关.
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