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关于CTAB与酸盐相互作用的结构研究:表面活性剂治疗与化疗敏感化效应的可能性

Anand A Sable¹, Minati Nayak¹, Sugam Kumar²

¹Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Mumbai 400085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India.

Journal of pharmaceutical sciences

|February 15, 2025

概括

制备了酸盐-乙三甲基胺纳米颗粒 (SANPs),显示CTAB度影响大小和形状. 这些SANP保留了抗癌活性,并增强了多克索鲁比辛在癌症治疗中的疗效.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

甲基酸盐和 cetyltrimethylammonium bromide (CTAB) 是具有药物输送潜力的生物相容聚合物.
纳米粒子配方在药物封装和有针对性的输送方面具有优势.
了解纳米粒子的结构-性质关系对于优化其性能至关重要.

研究的目的:

为了合成和表征基酸盐-乙三甲基化纳米颗粒 (SANPs).
研究CTAB度对SANP结构和特性的影响.
评估SANPs的抗癌活性和药物输送能力,包括含多克索鲁比的配方.

主要方法:

通过聚乙烯酸盐和CTAB的多电解质复合合成纳米粒子,度低于和高于临界微粒度 (CMC).
使用动态光散射,传输电子显微镜,小角度中子散射和泽塔电位测量的结构特征.
在A549和L132癌细胞系的体外细胞毒性测定和多克索鲁比释放研究.

主要成果:

CTAB度显著影响了SANP的水力动力学大小和形状.
用化CTAB (>CMC) 形成的SANP比用单体CTAB (
载有多克索鲁比的SANP显示出对癌细胞的增强细胞毒性,并表现出持续的,依赖pH的药物释放.

结论:

酸盐和CTAB的多电解质复合是一种创建新型纳米配方的可行策略.
SANPs具有固有的抗癌性质,可以有效地输送诸如多克索鲁比辛之类的化疗剂.
这些发现凸显了SANP在癌症治疗和药物输送应用中的潜力.

关键词:

阿尔金酸盐是一种酸盐.它具有抗癌活性.在CTABB中,它是最重要的.药物输送是药物输送的过程.纳米配方纳米配方纳米配方聚电解质复合的复杂化

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