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双AF对生殖和发育的生物学影响:我们到目前为止知道什么?

Megan V Alexander¹, Archana Ayyar¹, Alexandra W Gannon²

¹Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA.

Reproductive toxicology (Elmsford, N.Y.)

|February 15, 2025

概括

双AF (BPAF) 暴露会破坏内分泌功能和两性的人的生殖健康. 有证据表明,BPAF会影响发育,类固醇生成和生育能力,因此需要减少使用.

科学领域:

内分泌学在内分泌学.
生殖毒理学生殖毒理学
发展生物学发展生物学

背景情况:

比斯A (BPA) 的替代品,如比斯AF (BPAF),在工业制造中越来越多地使用.
有关BPAF对生殖和发育的影响存在担忧,需要进行全面审查.

研究的目的:

调查双AF (BPAF) 暴露与其对生殖和早期发育的影响之间的关系.
综合当前关于BPAF内分泌干扰和生殖效应的科学文献.

主要方法:

通过使用主要的科学数据库 (PubMed,Medline,Embase,Cochrane,ClinicalTrials.gov) 进行了系统的文献审查,直到2024年12月.
包含了125个体外,体内 (模型生物) 和人体研究,分析了对生殖生理学和发育的影响.

主要成果:

双AF (BPAF) 作为一种强大的选择性雌激素受体调节剂和雄激素受体对抗剂,超过了BPA的效力.
在各种人类生物样本中检测到BPAF,这表明暴露范围广泛.
研究表明,BPAF对下丘脑-垂体-腺轴,类固醇生成,胚胎生成,性差异化和两性伴侣细胞活力的不良影响.

结论:

汇聚的证据表明,双AF (BPAF) 对生殖健康和胚胎发育有明显的破坏性影响.
建议进行进一步的研究,但目前的发现强烈支持限制BPAF和类似双的使用.

关键词:

这是BPAF的BPAF.双二醇 (Bisphenol) 是一种二醇.双 AF AF 是一种双.发展发展发展发展发展生殖生殖生殖生殖繁殖

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