患者特征,表现,致病微生物和总体死亡率在丹麦国家内心炎研究 (NIDUS) 注册表中
Katra Hadji-Turdeghal1, Peter Laursen Graversen1, Jacob Eifer Møller2
1Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
American heart journal
|February 15, 2025
概括
丹麦国家内心炎研究 (NIDUS) 注册表提供了传染性内心炎 (IE) 的现实世界视图,显示年长的患者具有类似的并发症,但手术较少. 这些全国性数据将选择偏差降到最低,以便更清楚地了解IE.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 关于传染性内心炎 (IE) 的现有知识往往来自第三级医院队列,引入转诊偏差.
- 需要从未选择的患者群体获得全面的数据,以更好地了解IE.
- 丹麦国家内心炎研究 (NIDUS) 登记册是为了弥补这一缺口而建立的.
研究的目的:
- 在未经选择的全国患者队列中对传染性内心炎 (IE) 进行表征.
- 提供关于IE流行病学,临床表现和结果的细粒度,现实世界的数据.
- 为了最大限度地减少以往IE研究中固有的选择偏差.
主要方法:
- 利用了丹麦国家内心炎研究 (NIDUS) 注册表,涵盖了2016年至2021年期间所有丹麦内心炎诊断住院病例.
- 根据欧洲心脏病学会2015年标准,使用电子病历 (EMR) 验证了IE诊断.
- 包括3557名患者,其中2832人被归类为确定的IE,725人可能IE.
主要成果:
- 这项研究包括3557名IE患者 (平均年龄为73.7岁,68.3%为男性).
- 常见的并发病包括糖尿病 (23.7%),心力衰竭 (18.7%) 和慢性病 (17.4%).
- 住院死亡率为17.3%,一年死亡率为31.3%,金色葡萄球菌是最常见的病因 (31.9%).
结论:
- NIDUS注册表提供了一个全面的,全国性的IE数据集,最大限度地减少选择偏差.
- 在这个未经选择的队列中,IE患者年龄较大,具有相似的并发症负担,并且与三级中心研究相比,接受手术的频率较低.
- 这个注册表提供了IE在现实世界临床环境中的更清晰的图像.
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