在参加生育中心的男性中,与丸功能标志物相关的感知压力
Akshay G Reddy1, Paige L Williams2, Irene Souter3
1Department of Urology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Fertility and sterility
|February 15, 2025
概括
男性的高心理压力与精子数量较低和精子形态较差有关. 这项研究发现,压力会对特定的精液质量参数和精子DNA损伤产生负面影响,但不影响激素水平.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 安德罗学与人类学
- 男人的健康 男人的健康
背景情况:
- 心理压力是影响整体健康的一个普遍问题.
- 了解其对男性生殖功能的影响对于生育能力评估和治疗至关重要.
研究的目的:
- 调查自我报告的心理压力与精液参数之间的关联.
- 研究男性感知压力与生殖激素水平之间的关系.
主要方法:
- 一项观察性研究涉及718名18-55岁的男性在生育诊所.
- 精液和血清样本被分析了包括精子数,运动性,形态和DNA损伤 (彗星测试) 在内的参数.
- 通过感知压力量度 (PSS-4) 测量感知压力;通过血清分析量化生殖激素. 线性回归模型调整了混因子.
主要成果:
- 与压力较低的男性相比,感知压力最高的男性 (最高的PSS-4分数) 的调整平均精子总数和正常精子形态显着较低.
- 较高的压力水平与较低的精子度相关,减少了总运动细胞数量,并增加了具有高DNA损伤的精子细胞数量.
- 没有发现感知到的压力与其他精子DNA损伤标志物或生殖激素度之间的显著关联.
结论:
- 感知心理压力的增加与特定的精液质量参数负面相关,包括精子数和形态.
- 压力也与精子DNA损伤的增加有关,但并非所有DNA损伤标志物都受到影响.
- 在这个队列中,感知到的压力与测量的生殖激素水平没有关联.
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