超重醇A-H,是来自Hypericum wightianum的单类脱甲基化酸葡萄糖醇衍生物
Chuan-Lu Fu1, Ping Ying2, Zi-Wei Jia1
1Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
从Hypericum wightianum中发现了12种新的单类化合物. 两种化合物在细胞测试中显示出显著的氧化 (NO) 释放抑制,表明潜在的抗炎性质.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 超的物种是生物活性天然产品的丰富来源.
- 乙黄醇衍生物具有不同的药理活性.
研究的目的:
- 从Hypericum wightianum中分离和鉴定出新型的单基乙基醇衍生物.
- 评估隔离化合物的抗炎潜力.
主要方法:
- 使用色谱技术进行隔离和净化.
- 通过UV,HRMS和1D/2DNMR光谱学进行结构阐明.
- 使用奇拉HPLC和ECD计算来确定绝对配置.
主要成果:
- 在已知10种化合物之外,还发现了12种新化合物 - - 超重醇A-H (1-8).
- 化合物4和 (±) -14显示出强大的氧化物 (NO) 释放抑制作用.
- 化合物4和 (±) -14的IC50值在LPS诱导的RAW264.7细胞中确定.
结论:
- 这项研究扩大了单基酸黄醇的化学多样性.
- 化合物4和 (±) -14作为针对NO生产的抗炎药物具有前途.
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