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新型衍生物-复合物的双吸收途径提高了的生物可用性,并恢复了线粒体功能

Ximing Yang¹, Siyi Wang¹, Hanxiong Liu¹

¹SKL of Marine Food Processing & Safety Control, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China.

Journal of advanced research

|February 15, 2025

概括

一种来自的新型-复合物 (IE-Zn) 显著提高了的吸收和生物可用性. 这种先进的补充剂还通过促进线粒体功能和减少缺模型中的氧化应激来恢复能量代谢.

科学领域:

生物化学生物化学
营养科学营养科学
细胞生物学细胞生物学

背景情况:

缺乏是一个广泛的健康问题,影响免疫力,生长和能量代谢.
传统的补充剂具有有限的生物可用性,并受到饮食因素的影响.
衍生物-复合物 (IE-Zn) 为改善的输送和利用提供了一个潜在的解决方案.

研究的目的:

开发和评估一种新型-复合物 (IE-Zn),以提高的生物可用性.
研究IE-Zn改善的运输和细胞吸收背后的机制.
评估IE-Zn在恢复能量平衡和减轻缺乏症中氧化应激的有效性.

主要方法:

对Zn2+与衍生的IE结合的表征和结构灵活性的评估.
使用Caco-2和IEC-6细胞模型进行体外研究,以评估吸收和输送体表达 (ZIP4,PEPT1).
在缺的小鼠模型中进行体内研究,以评估的吸收,分布和对能量代谢信号通路 (AMPK/PGC1-α/NRF-1/TFAM) 的影响.

主要成果:

IE-Zn证明了Zn2+与IE的高亲和结合,通过离子和寡载体促进了运输.
与ZnSO4相比,IE-Zn在Caco-2和IEC-6细胞中显著增强了的吸收和保留,并上调了ZIP4和PEPT1.
在体内,IE-Zn改善了的吸收和分布,恢复了能量平衡,促进了线粒体生物发生,并减少了小鼠的氧化应激.

结论:

与传统的硫酸相比,IE-Zn具有更高的生物利用性和吸收性.
IE-Zn有效地恢复细胞能量代谢,并减轻与缺乏相关的氧化应激.
像IE-Zn这样的酸矿物复合物在营养补充和管理与缺乏相关的疾病方面具有显著的治疗潜力.

关键词:

在AMPK/PGC1-α/NRF-1/TFAM信号通路中.两个吸收途径.线粒体功能线粒体功能 -复合体是一种复合体.的生物利用性的生物利用性

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