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Updated: May 27, 2025

Detection of Toxin Translocation into the Host Cytosol by Surface Plasmon Resonance
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Detection of Toxin Translocation into the Host Cytosol by Surface Plasmon Resonance

Published on: January 3, 2012

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在氨酸A子单元的P茎部位的小分子结合会引发延伸到活性部位的构造变化

John E McLaughlin1, Michael J Rudolph2, Arkajyoti Dutta1

  • 1Department of Plant Biology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA.

The Journal of biological chemistry
|February 15, 2025
PubMed
概括

一种新的化合物通过结合素毒素A亚单元 (RTA) P-茎口袋,有效地抑制素毒素和Shiga毒素 (Stx). 这一发现为对抗这些危险的生物恐怖分子提供了有希望的治疗策略.

关键词:
石加毒素抑制剂 石加毒素抑制剂通过NMR进行的形状变化.核糖体结合 核糖体结合里辛抑制剂的使用基于结构的设计设计.

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