在患有牛皮关节炎的患者中,阿普雷米拉斯特的心脏代谢作用:一项前性队列研究
Romy Hansildaar1, Eva H van Geel2, Fatih Çoban3
1R. Hansildaar, MD, Amsterdam Rheumatology and Immunology Center, Reade, and Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Center, and Department of Rheumatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
The Journal of rheumatology
|February 15, 2025
概括
在牛皮性关节炎 (PsA) 患者中,阿普雷米拉斯特治疗显著减少了体脂质量和改善了疾病活动. 这些发现表明潜在的心血管和代谢益处,需要进一步调查PsA管理.
科学领域:
- 类风湿病学 类风湿病学
- 心血管医学 心血管医学
- 代谢健康 代谢健康
背景情况:
- 牛皮关节炎 (PsA) 与增加代谢和心血管疾病风险有关.
- 在之前的研究中,阿普雷米拉斯特已经显示出减肥和心脏代谢改善的潜力.
- 阿普雷米拉斯特对身体组成和心血管风险因素在PsA的影响需要进一步研究.
研究的目的:
- 研究阿普雷米拉斯特对活跃PSA患者的体重,身体组成和心血管风险因素的影响.
- 为了评估12个月内脂肪质量,肌肉质量,血压,脂质和葡萄糖代谢的变化.
- 评估身体成分变化与疾病活动之间的相关性.
主要方法:
- 一个为期12个月的纵向,非随机化,多中心试验,涉及成人活跃的PsA启动apremilast.
- 主要结局:通过双能X射线吸收计评估身体成分.
- 二次结局:28个关节的疾病活动评分 (DAS28-CRP),血压,脂质,内膜厚度和葡萄糖水平.
主要成果:
- 在Apremilast治疗1年后,总脂肪量 (-7.4公斤) 和安卓脂肪量 (-1.1公斤) 显著减少.
- 瘦肉质量保持稳定;血压略有下降,而脂质,内膜厚度和葡萄糖水平没有显著变化.
- 阿普雷米拉斯特治疗改善了PsA疾病活动 (DAS28-CRP减少了-0.6),安卓脂肪减少与疾病活动改善有很强的相关性 (r=0.31).
结论:
- 在患有牛皮关节炎的患者中,阿普雷米拉斯特治疗有效减少脂肪质量.
- 这项研究表明,在PsA治疗中,与阿普雷米拉斯治疗相关的潜在心血管和代谢益处.
- 阿普雷米拉斯特可以通过改善身体组成和疾病活动来减少PsA患者心血管事件的风险.
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