患有牛皮关节炎的年轻成年人的退行性磁盘疾病
Fadi Kharouf1, Shangyi Gao2, Daniel Pereira3
1F. Kharouf, MD, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto.
The Journal of rheumatology
|February 15, 2025
概括
退行性磁盘疾病 (DDD) 在年轻的牛皮关节炎 (PsA) 患者中很常见,与年龄,男性性别,糖尿病和炎症性背痛 (IBP) 有关. 在这项研究中,成像发现与背部疼痛类型无关.
科学领域:
- 类风湿病学 类风湿病学
- 整形外科 整形外科 整形外科
- 放射学 放射学是一门学科.
背景情况:
- 牛皮关节炎 (PsA) 可以影响脊椎,导致各种肌肉骨并发症.
- 退行性磁盘疾病 (DDD) 是背部疼痛的常见原因,但其在年轻的PsA患者中的患病率和相关性尚未明确.
研究的目的:
- 为了确定50岁以下的PsA患者中DDD的患病率.
- 在这个人群中确定与DDD发展相关的因素.
- 为了检查放射性脊柱发现和炎症与机械背痛之间的关系.
主要方法:
- 对814名PsA患者 (<50岁) 的前性观察队列研究.
- 通过放射性标志 (盘间狭窄,骨质细胞等) 定义的DDD. 在脊柱放射图上.
- 用于分析的多变量考克斯回归和概括估计方程 (GEE).
主要成果:
- 38.8%的PsA患者在脊柱放射图上表现出DDD.
- 与DDD相关的因素包括年龄,男性性别,糖尿病和炎症性背痛 (IBP).
- 放射性发现 (DDD,轴性疾病) 和背部疼痛类型 (IBP或机械) 之间没有发现显著的关联.
结论:
- 退行性磁盘疾病在年轻的PsA患者中很普遍.
- 人口,并发症和与疾病相关的因素影响DDD的发展.
- 炎症性背痛不是一个可靠的指标,可以区分轴向PsA和DDD.
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